Nes
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.
Full Name
Nestin
Alternative Names
Nestin; Nbla00170;
Function
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
Biological Process
Brain development Source: UniProtKB
Cell projection morphogenesis Source: Ensembl
Central nervous system development Source: UniProtKB
Embryonic camera-type eye development Source: UniProtKB
G2/M transition of mitotic cell cycle Source: DFLAT
Negative regulation of catalytic activity Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of protein binding Source: UniProtKB
Positive regulation of intermediate filament depolymerization Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Stem cell proliferation Source: DFLAT
Cell projection morphogenesis Source: Ensembl
Central nervous system development Source: UniProtKB
Embryonic camera-type eye development Source: UniProtKB
G2/M transition of mitotic cell cycle Source: DFLAT
Negative regulation of catalytic activity Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of protein binding Source: UniProtKB
Positive regulation of intermediate filament depolymerization Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Stem cell proliferation Source: DFLAT
Cellular Location
Cytoskeleton
intermediate filament
intermediate filament cytoskeleton
Other locations
cytoplasm
intermediate filament
intermediate filament cytoskeleton
Other locations
cytoplasm
PTM
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
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Anti-Nes antibodies
+ Filters
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CompareTarget: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G2F7
Application*: E, WB, IH, IF, F
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 2Q178
Application*: IF, IC, C, P, IM, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 4D4
Application*: IF, IC, C, P, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse
Clone: 307501
Application*: IC, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 401
Application*: EM, F, IC, IF, C, P, WB
Target: NES
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 7A3
Application*: IC, IF, C
Target: NES
Host: Rat
Antibody Isotype: IgM
Specificity: Chicken
Clone: A2B11
Application*: E
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3070
Application*: WB, F
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3452
Application*: WB, F
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC198
Application*: IH
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A1327
Application*: ICC, IHC, IP, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1326
Application*: IHC
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1325
Application*: IF, IHC, IP, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A1324
Application*: ELISA, FC, IF, IHC, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: A1323
Application*: ICC, IHC, IP, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A1322
Application*: ELISA, IF, IHC, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1321
Application*: ICC, IHC, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB144A
Application*: ELISA, WB, IHC, IF, FC
Target: NES
Host: Mouse
Antibody Isotype: IgM, λ
Specificity: Human
Clone: IHC638
Application*: P, E, IH
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBWJN-0785
Application*: WB, IF, IH, IP
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9A19
Application*: WB, IH, IC, IF
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C93
Application*: E, IC, IH, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4D11
Application*: WB, IF
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3k1
Application*: F, IC
Target: NES
Host: Mouse
Specificity: Mouse, Rat
Clone: CBWJN-0014
Application*: WB, IP, IF, P, F
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0333
Application*: IC, IH, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1D11H2
Application*: E, WB, IH, IF
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: WB, IH
Target: NES
Host: Mouse
Specificity: Human
Clone: CBWJN-0210
Application*: E, F, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0163
Application*: IC, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0117
Application*: F
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1332
Application*: E, P, IC
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBWJN-0867
Application*: P, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0436
Application*: E, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0365
Application*: E, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0335
Application*: WB, IC, F, P, IP
Target: NES
Host: Mouse
Specificity: Human
Clone: CBWJN-0334
Application*: E, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human
Clone: CBWJN-0304
Application*: WB
Target: NES
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBWJN-0977
Application*: WB, IC
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0976
Application*: F, IC, MC
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBWJN-0975
Application*: WB, P, C, IC
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP103
Application*: F, IF, P, WB
Target: NES
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 196908
Application*: E, F, IC, IF, IH, C, IP, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C2
Application*: IF, C, P, WB
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1.3A11
Application*: F, IC, P, IP, WB
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0123
Application*: F, IF, P
Target: NES
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Mouse
Application*: IF, IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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