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Nes

This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Full Name
Nestin
Function
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
Biological Process
Brain development Source: UniProtKB
Cell projection morphogenesis Source: Ensembl
Central nervous system development Source: UniProtKB
Embryonic camera-type eye development Source: UniProtKB
G2/M transition of mitotic cell cycle Source: DFLAT
Negative regulation of catalytic activity Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of protein binding Source: UniProtKB
Positive regulation of intermediate filament depolymerization Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Stem cell proliferation Source: DFLAT
Cellular Location
Cytoskeleton
intermediate filament
intermediate filament cytoskeleton
Other locations
cytoplasm
PTM
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).

Anti-Nes antibodies

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Mouse Anti-NES Monoclonal Antibody (2Q178) (CBMAB-1415-YC)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 2Q178
Application*: IF, IC, C, P, IM, WB

Mouse Anti-NES Monoclonal Antibody (4D4) (CBMAB-1414-YC)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 4D4
Application*: IF, IC, C, P, WB

Mouse Anti-NES Monoclonal Antibody (307501) (CBMAB-1413-YC)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse
Clone: 307501
Application*: IC, WB

Mouse Anti-NES Monoclonal Antibody (401) (CBMAB-1412-YC)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 401
Application*: EM, F, IC, IF, C, P, WB

Rat Anti-NES Monoclonal Antibody (7A3) (CBMAB-1411-YC)

Datasheet SDS
Target: NES
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 7A3
Application*: IC, IF, C

Rabbit Anti-NES Recombinant Antibody (SP103) (CBMAB-0513CQ)

Datasheet SDS
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP103
Application*: F, IF, P, WB

Human Anti-NES Recombinant Antibody (196908) (CBMAB-0512CQ)

Datasheet SDS
Target: NES
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 196908
Application*: E, F, IC, IF, IH, C, IP, WB

Mouse Anti-NES Recombinant Antibody (10C2) (CBMAB-0511CQ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C2
Application*: IF, C, P, WB

Mouse Anti-NES Recombinant Antibody (2C1.3A11) (CBMAB-0510CQ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1.3A11
Application*: F, IC, P, IP, WB

Rabbit Anti-NES Recombinant Antibody (BA0123) (CBMAB-0509CQ)

Datasheet SDS
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0123
Application*: F, IF, P

Mouse Anti-NES Recombinant Antibody (CBWJN-0785) (CBMAB-N1999-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBWJN-0785
Application*: WB, IF, IH, IP

Mouse Anti-NES Recombinant Antibody (9A19) (CBMAB-N1996-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9A19
Application*: WB, IH, IC, IF

Mouse Anti-NES Recombinant Antibody (5C93) (CBMAB-N1994-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C93
Application*: E, IC, IH, WB

Mouse Anti-NES Recombinant Antibody (4D11) (CBMAB-N1992-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4D11
Application*: WB, IF

Mouse Anti-NES Recombinant Antibody (3k1) (CBMAB-N1991-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3k1
Application*: F, IC

Mouse Anti-NES Recombinant Antibody (CBWJN-0014) (CBMAB-N1990-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Specificity: Mouse, Rat
Clone: CBWJN-0014
Application*: WB, IP, IF, P, F

Mouse Anti-NES Recombinant Antibody (CBWJN-0333) (CBMAB-N1989-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0333
Application*: IC, IH, WB

Mouse Anti-NES Recombinant Antibody (1D11H2) (CBMAB-N1988-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1D11H2
Application*: E, WB, IH, IF

Mouse Anti-NES Recombinant Antibody (1B4) (CBMAB-N1987-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: WB, IH

Mouse Anti-NES Recombinant Antibody (CBWJN-0210) (CBMAB-N1982-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Specificity: Human
Clone: CBWJN-0210
Application*: E, F, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0163) (CBMAB-N1981-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0163
Application*: IC, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0117) (CBMAB-N1980-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0117
Application*: F

Mouse Anti-NES Recombinant Antibody (CBWJN-1332) (CBMAB-N1979-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1332
Application*: E, P, IC

Rabbit Anti-NES Recombinant Antibody (CBWJN-0867) (CBMAB-N0265-WJ)

Datasheet SDS
Target: NES
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBWJN-0867
Application*: P, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0436) (CBMAB-N0262-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0436
Application*: E, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0365) (CBMAB-N0261-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0365
Application*: E, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0335) (CBMAB-N0260-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0335
Application*: WB, IC, F, P, IP

Mouse Anti-NES Recombinant Antibody (CBWJN-0334) (CBMAB-N0259-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Specificity: Human
Clone: CBWJN-0334
Application*: E, WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0304) (CBMAB-N0257-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human
Clone: CBWJN-0304
Application*: WB

Mouse Anti-NES Recombinant Antibody (CBWJN-0977) (CBMAB-N0255-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBWJN-0977
Application*: WB, IC

Mouse Anti-NES Recombinant Antibody (CBWJN-0976) (CBMAB-N0254-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0976
Application*: F, IC, MC

Mouse Anti-NES Recombinant Antibody (CBWJN-0975) (CBMAB-N0253-WJ)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBWJN-0975
Application*: WB, P, C, IC

Mouse Anti-NES Recombinant Antibody (A1327) (CBMAB-AP5016LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A1327
Application*: ICC, IHC, IP, WB

Mouse Anti-NES Recombinant Antibody (A1326) (CBMAB-AP5014LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1326
Application*: IHC

Mouse Anti-NES Recombinant Antibody (A1325) (CBMAB-AP12543LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1325
Application*: IF, IHC, IP, WB

Mouse Anti-NES Recombinant Antibody (A1324) (CBMAB-AP5023LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A1324
Application*: ELISA, FC, IF, IHC, WB

Mouse Anti-NES Recombinant Antibody (A1323) (CBMAB-AP5018LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: A1323
Application*: ICC, IHC, IP, WB

Mouse Anti-NES Recombinant Antibody (A1322) (CBMAB-AP12541LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A1322
Application*: ELISA, IF, IHC, WB

Mouse Anti-NES Recombinant Antibody (A1321) (CBMAB-AP5015LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1321
Application*: ICC, IHC, WB

Mouse Anti-NES Recombinant Antibody (CB144A) (CBMAB-CA144LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB144A
Application*: ELISA, WB, IHC, IF, FC

Mouse Anti-NES Recombinant Antibody (IHC638) (CBMAB-MA185-YC)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgM, λ
Specificity: Human
Clone: IHC638
Application*: P, E, IH

Mouse Anti-NES Recombinant Antibody (2G2F7) (CBMAB-R4243-CN)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G2F7
Application*: E, WB, IH, IF, F

Rat Anti-NES Recombinant Antibody (A2B11) (CBMAB-0332-CN)

Datasheet SDS
Target: NES
Host: Rat
Antibody Isotype: IgM
Specificity: Chicken
Clone: A2B11
Application*: E

Mouse Anti-Nes Recombinant Antibody (CBMAB-0635-LY)

Datasheet SDS
Target: NES
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Mouse
Application*: IF, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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