NKG2D

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha.

Full Name

killer cell lectin-like receptor subfamily K, member 1

Function

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell differentiationIEA:UniProtKB-KW
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:MGI
Natural killer cell activationManual Assertion Based On ExperimentIMP:MGI
Natural killer cell mediated cytotoxicityIEA:Ensembl
Negative regulation of GTPase activityIEA:Ensembl
Negative regulation of natural killer cell chemotaxisIEA:Ensembl
Positive regulation of apoptotic processISO:MGI
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:MGI
Positive regulation of myeloid dendritic cell activationISO:MGI
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetISO:MGI
Positive regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:MGI
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cell membrane
Colocalized with HCST and TYROBP on the cell surface.

Involvement in disease

Involved in autoreactive CD8(+) T-cell-mediated development of autoimmune diabetes.

Topology

Cytoplasmic: 1-66
Helical: 67-89
Extracellular: 90-232