Sign in or Register

Nr3c2

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Full Name
Nr3c2
Function
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Biological Process
Intracellular steroid hormone receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Endoplasmic reticulum membrane
Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Involvement in disease
Pseudohypoaldosteronism 1, autosomal dominant (PHA1A):
A salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1A is a mild form characterized by target organ defects confined to kidney. Patients may present with neonatal renal salt wasting with hyperkalaemic acidosis despite high aldosterone levels. These patients improve with age and usually become asymptomatic without treatment.
Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP):
Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.
PTM
Phosphorylated.
View more

Anti-Nr3c2 antibodies

+ Filters
Loading...

Mouse Anti-Nr3c2 Recombinant Antibody (1D5) (CBMAB-0435-LY)

Go to compareCompare
Target: Nr3c2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Dog, Chicken, Human, Mouse, Rabbit
Clone: 1D5
Application*: CI, E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-NR3C2 (AA 2-99) Recombinant Antibody (CBFYM-3035) (CBMAB-M3231-FY)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-3035
Application*: WB, IH, IP, E
Datasheet SDS

Mouse Anti-NR3C2 (AA 1-670) Recombinant Antibody (CBFYM-3034) (CBMAB-M3230-FY)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-3034
Application*: WB, IH
Datasheet SDS

Mouse Anti-NR3C2 Recombinant Antibody (CBFYM-3033) (CBMAB-M3229-FY)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Rabbit, Rat
Clone: CBFYM-3033
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-NR3C2 Recombinant Antibody (H10E4C9F) (CBMAB-N3451-WJ)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Rabbit, Rat
Clone: H10E4C9F
Application*: F, IC, IF, P, IH, I, WB
Datasheet SDS

Mouse Anti-NR3C2 Recombinant Antibody (2B5) (CBMAB-N3450-WJ)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B5
Application*: E, WB
Datasheet SDS

Mouse Anti-NR3C2 Recombinant Antibody (CBWJN-1535) (CBMAB-N3449-WJ)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1535
Application*: P, WB
Datasheet SDS

Mouse Anti-Nr3c2 Antibody (3F10) (CBMAB-0880-YC)

Go to compareCompare
Target: Nr3c2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Mouse
Clone: 3F10
Application*: IF, IH, IC
Datasheet SDS

Mouse Anti-Nr3c2 Antibody (2B7) (CBMAB-0879-YC)

Go to compareCompare
Target: Nr3c2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: 2B7
Application*: IH, WB
Datasheet SDS

Mouse Anti-NR3C2 Antibody (1E3) (CBMAB-0758-YC)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Common fruit fly
Clone: 1E3
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-NR3C2 Antibody (1A3) (CBMAB-0757-YC)

Go to compareCompare
Target: NR3C2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Common fruit fly
Clone: 1A3
Application*: E, IP
Datasheet SDS

Mouse Anti-Nr3c2 Recombinant Antibody (4D6) (CBMAB-0436-LY)

Go to compareCompare
Target: Nr3c2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse
Clone: 4D6
Application*: IF, IH, IP, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry