NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Full Name
Neuregulin 4
Function
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Biological Process
Nervous system developmentIEA:InterPro
Cellular Location
Pro-neuregulin-4, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-4
Secreted
Topology
Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-115
PTM
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.
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Anti-NRG4 antibodies

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Mouse Anti-NRG4 Recombinant Antibody (A1395) (CBMAB-AP5044LY)

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Target: NRG4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A1395
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684) (CBMAB-H3739-FY)

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Target: NRG4
Host: Mouse
Specificity: Human
Clone: CBFYH-2684
Application*: WB, IC, P, C, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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