NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Full Name
Neuregulin 4
Function
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Biological Process
Nervous system developmentIEA:InterPro
Cellular Location
Pro-neuregulin-4, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-4
Secreted
Topology
Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-115
PTM
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.
View more

Anti-NRG4 antibodies

+ Filters
Loading...

Mouse Anti-NRG4 Recombinant Antibody (A1395) (CBMAB-AP5044LY)

Go to compareCompare
Target: NRG4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A1395
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684) (CBMAB-H3739-FY)

Go to compareCompare
Target: NRG4
Host: Mouse
Specificity: Human
Clone: CBFYH-2684
Application*: WB, IC, P, C, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry