Human Recombinant NRG4 protein (V2LY-0526-LY5758)

Name: Human Recombinant NRG4 protein
SKU: V2LY-0526-LY5758
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant NRG4 protein consist of Amino Acid: 2-62 and predicts a molecular mass of 6.7 kDa.

Molecule Mass

6.7 kDa

Sequence

Amino Acid: 2-62

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>92% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Neuregulin 4

Function

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

Biological Process

Nervous system developmentIEA:InterPro

Cellular Location

Pro-neuregulin-4, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-4
Secreted

Topology

Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-115

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.

Chen, M., Zhu, J., Luo, H., Mu, W., & Guo, L. (2023). The journey towards physiology and pathology: Tracing the path of neuregulin 4. Genes & Diseases.

Liu, Y., & Chen, M. (2023). Neuregulin 4 as a novel adipokine in energy metabolism. Frontiers in Physiology, 13, 1106380.

Attique, H., Baig, S., Ishtiaque, S., Rehman, R., Ahmed, S. T., & Ali Shahid, M. (2022). Neuregulin 4 (NRG4)–the hormone with clinical significance in gestational diabetes mellitus. Journal of Obstetrics and Gynaecology, 42(6), 1931-1936.

Tutunchi, H., Mobasseri, M., Aghamohammadzadeh, N., Hooshyar, J., Naeini, F., & Najafipour, F. (2021). Serum neuregulin 4 (NRG‐4) level and non‐alcoholic fatty liver disease (NAFLD): A case‐control study. International Journal of Clinical Practice, 75(10), e14555.

Howard, L., Wyatt, S., & Davies, A. M. (2021). Neuregulin‐4 contributes to the establishment of cutaneous sensory innervation. Developmental Neurobiology, 81(2), 139-148.

Tutunchi, H., Ostadrahimi, A., Hosseinzadeh‐Attar, M. J., Miryan, M., Mobasseri, M., & Ebrahimi‐Mameghani, M. (2020). A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances. Obesity reviews, 21(2), e12952.

Rahimzadeh, M., Farshidi, N., Naderi, N., Farshidi, H., & Montazerghaem, H. (2020). Clinical significance of serum concentrations of neuregulin-4, in acute coronary syndrome. Scientific Reports, 10(1), 5797.

Kocak, M. Z., Aktas, G., Atak, B. M., Duman, T. T., Yis, O. M., Erkus, E., & Savli, H. (2020). Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus?. European journal of clinical investigation, 50(3), e13206.

Tian, Q. P., Liu, M. L., Tang, C. S., Xue, L., Pang, Y. Z., & Qi, Y. F. (2019). Association of circulating neuregulin-4 with presence and severity of coronary artery disease. International heart journal, 60(1), 45-49.

Blüher, M. (2019). Neuregulin 4: A “hotline” between brown fat and liver. Obesity, 27(10), 1555-1557.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Nrg4 ELISA Kit (CAT#: V2LY-0626-LY2753)

Related Products

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Mouse Nrg4 ELISA Kit (CAT#: V2LY-0626-LY2753)

Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684) (CAT#: CBMAB-H3739-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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