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Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684) (CBMAB-H3739-FY)

This product is mouse antibody that recognizes NRG4. The antibody CBFYH-2684 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all NRG4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2684
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuregulin 4
Introduction
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
Entrez Gene ID
145957
UniProt ID
Q8WWG1
Alternative Names
Neuregulin 4; Pro-NRG4; Pro-Neuregulin-4, Membrane-Bound Isoform; Heregulin 4; HRG4
Function
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Biological Process
Nervous system developmentIEA:InterPro
Cellular Location
Pro-neuregulin-4, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-4
Secreted
Topology
Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-115
PTM
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.

Chen, M., Zhu, J., Luo, H., Mu, W., & Guo, L. (2023). The journey towards physiology and pathology: Tracing the path of neuregulin 4. Genes & Diseases.

Liu, Y., & Chen, M. (2023). Neuregulin 4 as a novel adipokine in energy metabolism. Frontiers in Physiology, 13, 1106380.

Attique, H., Baig, S., Ishtiaque, S., Rehman, R., Ahmed, S. T., & Ali Shahid, M. (2022). Neuregulin 4 (NRG4)–the hormone with clinical significance in gestational diabetes mellitus. Journal of Obstetrics and Gynaecology, 42(6), 1931-1936.

Tutunchi, H., Mobasseri, M., Aghamohammadzadeh, N., Hooshyar, J., Naeini, F., & Najafipour, F. (2021). Serum neuregulin 4 (NRG‐4) level and non‐alcoholic fatty liver disease (NAFLD): A case‐control study. International Journal of Clinical Practice, 75(10), e14555.

Howard, L., Wyatt, S., & Davies, A. M. (2021). Neuregulin‐4 contributes to the establishment of cutaneous sensory innervation. Developmental Neurobiology, 81(2), 139-148.

Tutunchi, H., Ostadrahimi, A., Hosseinzadeh‐Attar, M. J., Miryan, M., Mobasseri, M., & Ebrahimi‐Mameghani, M. (2020). A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances. Obesity reviews, 21(2), e12952.

Rahimzadeh, M., Farshidi, N., Naderi, N., Farshidi, H., & Montazerghaem, H. (2020). Clinical significance of serum concentrations of neuregulin-4, in acute coronary syndrome. Scientific Reports, 10(1), 5797.

Kocak, M. Z., Aktas, G., Atak, B. M., Duman, T. T., Yis, O. M., Erkus, E., & Savli, H. (2020). Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus?. European journal of clinical investigation, 50(3), e13206.

Tian, Q. P., Liu, M. L., Tang, C. S., Xue, L., Pang, Y. Z., & Qi, Y. F. (2019). Association of circulating neuregulin-4 with presence and severity of coronary artery disease. International heart journal, 60(1), 45-49.

Blüher, M. (2019). Neuregulin 4: A “hotline” between brown fat and liver. Obesity, 27(10), 1555-1557.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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