Mouse Nrg4 ELISA Kit (V2LY-0626-LY2753)

Name: Mouse Nrg4 ELISA Kit
SKU: V2LY-0626-LY2753
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.54 ng/mL

Detection Range

1-400 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Mouse

Assay Type

Sandwich

Reactivity

Mouse

Assay Time

1.5 h

Molecule Mass

12.7 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Neuregulin 4

Function

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

Biological Process

Nervous system developmentIEA:InterPro

Cellular Location

Pro-neuregulin-4, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-4
Secreted

Topology

Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-115

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.

Chen, M., Zhu, J., Luo, H., Mu, W., & Guo, L. (2023). The journey towards physiology and pathology: Tracing the path of neuregulin 4. Genes & Diseases.

Liu, Y., & Chen, M. (2023). Neuregulin 4 as a novel adipokine in energy metabolism. Frontiers in Physiology, 13, 1106380.

Attique, H., Baig, S., Ishtiaque, S., Rehman, R., Ahmed, S. T., & Ali Shahid, M. (2022). Neuregulin 4 (NRG4)–the hormone with clinical significance in gestational diabetes mellitus. Journal of Obstetrics and Gynaecology, 42(6), 1931-1936.

Tutunchi, H., Mobasseri, M., Aghamohammadzadeh, N., Hooshyar, J., Naeini, F., & Najafipour, F. (2021). Serum neuregulin 4 (NRG‐4) level and non‐alcoholic fatty liver disease (NAFLD): A case‐control study. International Journal of Clinical Practice, 75(10), e14555.

Howard, L., Wyatt, S., & Davies, A. M. (2021). Neuregulin‐4 contributes to the establishment of cutaneous sensory innervation. Developmental Neurobiology, 81(2), 139-148.

Tutunchi, H., Ostadrahimi, A., Hosseinzadeh‐Attar, M. J., Miryan, M., Mobasseri, M., & Ebrahimi‐Mameghani, M. (2020). A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances. Obesity reviews, 21(2), e12952.

Rahimzadeh, M., Farshidi, N., Naderi, N., Farshidi, H., & Montazerghaem, H. (2020). Clinical significance of serum concentrations of neuregulin-4, in acute coronary syndrome. Scientific Reports, 10(1), 5797.

Kocak, M. Z., Aktas, G., Atak, B. M., Duman, T. T., Yis, O. M., Erkus, E., & Savli, H. (2020). Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus?. European journal of clinical investigation, 50(3), e13206.

Tian, Q. P., Liu, M. L., Tang, C. S., Xue, L., Pang, Y. Z., & Qi, Y. F. (2019). Association of circulating neuregulin-4 with presence and severity of coronary artery disease. International heart journal, 60(1), 45-49.

Blüher, M. (2019). Neuregulin 4: A “hotline” between brown fat and liver. Obesity, 27(10), 1555-1557.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NRG4 protein (CAT#: V2LY-0526-LY5758)

Related Products

Mouse Anti-NRG4 Recombinant Antibody (CBFYH-2684) (CAT#: CBMAB-H3739-FY)

Mouse Anti-NRG4 Recombinant Antibody (A1395) (CAT#: CBMAB-AP5044LY)

Human Recombinant NRG4 protein (CAT#: V2LY-0526-LY5758)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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