NUTM1

NUTM1 (NUT Midline Carcinoma Family Member 1) is a Protein Coding gene. Diseases associated with NUTM1 include Nut Midline Carcinoma and Extragonadal Nonseminomatous Germ Cell Tumor. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2G.

NUT Midline Carcinoma Family Member 1

Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.

Cytoplasm
Nucleus
Shuttles between nucleus and cytoplasm.

A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUTM1 fusion protein.
A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUTM1 fusion protein.

Methylated at Gln-1046 by N6AMT1.
Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.