OAZ1

OAZ1 belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of

Full Name

Ornithine Decarboxylase Antizyme 1

Function

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277).
Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948).
Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240).
Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).

Biological Process

Negative regulation of polyamine transmembrane transportIEA:Ensembl
Polyamine biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of intracellular protein transportISS:UniProtKB
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

cytoplasm
cytosol
nucleus