PAG1

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Adaptive immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of T cell activationManual Assertion Based On ExperimentIDA:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cell membrane

Extracellular: 1-16
Helical: 17-37
Cytoplasmic: 38-432

Palmitoylated.
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.