PAG1

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Full Name
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of T cell activationManual Assertion Based On ExperimentIDA:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-16
Helical: 17-37
Cytoplasmic: 38-432
PTM
Palmitoylated.
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
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Anti-PAG1 antibodies

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Mouse Anti-PAG1 Recombinant Antibody (CBLC247-LY) (CBMAB-C12155-LY)

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Target: PAG1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLC247-LY
Application*: WB, IP
Datasheet SDS

Mouse Anti-PAG1 Recombinant Antibody (CBXC-1724) (CBMAB-C5800-CQ)

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Target: PAG1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1724
Application*: WB, IP
Datasheet SDS

Mouse Anti-PAG1 Recombinant Antibody (PAG-C1) (CBMAB-P0669-YC)

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Target: PAG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Cattle
Clone: PAG-C1
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-PAG1 Recombinant Antibody (MEM-255) (CBMAB-P0668-YC)

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Target: PAG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MEM-255
Application*: F, P, WB
Datasheet SDS

Mouse Anti-PAG1 Recombinant Antibody (CBYY-C2709) (CBMAB-C4150-YY)

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Target: PAG1
Host: Mouse
Specificity: Human, Mouse
Clone: CBYY-C2709
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-PAG1 Recombinant Antibody (3F310) (CBMAB-C0351-YY)

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Target: PAG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Mouse, Rat
Clone: 3F310
Application*: IH, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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