Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PAG1 Recombinant Antibody (MEM-255) (CBMAB-P0668-YC)


See all PAG1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
MEM-255
Antibody Isotype
IgG2a
Application
FC, IHC-P, WB

Basic Information

Immunogen
Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 15 mM sodium azide, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1
Introduction
PAG1 is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
Entrez Gene ID
55824
UniProt ID
Q9NWQ8
Alternative Names
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1; Csk-Binding Protein; Phosphoprotein Associated With Glycosphingolipid Microdomains 1; Transmembrane Adaptor Protein PAG; Transmembrane Adapter Protein PAG; Transmembrane Phosphoprotein Cbp; CBP; PAG; Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1;
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of T cell activationManual Assertion Based On ExperimentIDA:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-16
Helical: 17-37
Cytoplasmic: 38-432
PTM
Palmitoylated.
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PAG1 Recombinant Antibody (MEM-255)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry