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Mouse Anti-PAG1 Recombinant Antibody (CBLC247-LY) (CBMAB-C12155-LY)

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Basic Information

Host Animal
Mouse
Clone
CBLC247-LY
Application
WB, IP
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1
Introduction
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human55824
Mouse94212
Rat64019
UniProt ID
HumanQ9NWQ8
MouseQ3U1F9
RatQ9JM80
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of T cell activationManual Assertion Based On ExperimentIDA:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-16
Helical: 17-37
Cytoplasmic: 38-432
PTM
Palmitoylated.
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.

Sun, Y., Yang, X., Guan, S., Ma, T., Jiang, Z., Gao, M., ... & Cong, B. (2023). The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma. Archives of Oral Biology, 156, 105810.

Abd el-Aziz, A., El-Desouky, M. A., Shafei, A., Elnakib, M., & Abdelmoniem, A. M. (2021). Influence of pentoxifylline on gene expression of PAG1/miR-1206/SNHG14 in ischemic heart disease. Biochemistry and Biophysics Reports, 25, 100911.

Foltz, L., Palacios-Moreno, J., Mayfield, M., Kinch, S., Dillon, J., Syrenne, J., ... & Grimes, M. (2020). PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. Molecular Biology of the Cell, 31(20), 2269-2282.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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