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Mouse Anti-PAG1 Recombinant Antibody (PAG-C1) (CBMAB-P0669-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1. The antibody can be used for immunoassay techniques, such as WB, IHC, IHC-P.
See all PAG1 antibodies
Published Data
Fig.1 Src phosphorylation leads to its subcellular redistribution.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
PAG-C1
Antibody Isotype
IgG2b
Application
WB, IHC, IHC-P

Basic Information

Immunogen
C-terminal peptide (last 15 amino acids) of human Csk binding protein coupled to KLH
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1
Introduction
PAG1 is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
Entrez Gene ID
Human55824
Mouse94212
Rat64019
Cattle281964
UniProt ID
HumanQ9NWQ8
MouseQ3U1F9
RatQ9JM80
CattleF1MQC1
Alternative Names
Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1; Csk-Binding Protein; Phosphoprotein Associated With Glycosphingolipid Microdomains 1; Transmembrane Adaptor Protein PAG; Transmembrane Adapter Protein PAG; Transmembrane Phosphoprotein Cbp; CBP; PAG; Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1;
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of T cell activationManual Assertion Based On ExperimentIDA:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-16
Helical: 17-37
Cytoplasmic: 38-432
PTM
Palmitoylated.
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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