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PDE1A

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+).

Full Name

Phosphodiesterase 1A

Function

Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.

Biological Process

Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol
neuronal cell body

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Anti-PDE1A antibodies

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Mouse Anti-PDE1A Recombinant Antibody (5C9) (CBMAB-P1185-YC)

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Target: PDE1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C9

Application*: WB

Mouse Anti-PDE1A Recombinant Antibody (7D5) (CBMAB-P1187-YC)

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Target: PDE1A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7D5

Application*: WB, IH

Mouse Anti-PDE1A Recombinant Antibody (5H4) (CBMAB-P1186-YC)

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Target: PDE1A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5H4

Application*: WB

Human Recombinant PDE1A, Active protein, His Tag (V2LY-0526-LY6024)

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Target: PDE1A

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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