PDE1A

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+).

Full Name

Phosphodiesterase 1A

Function

Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.

Biological Process

Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol
neuronal cell body

Anti-PDE1A antibodies

Mouse Anti-PDE1A Recombinant Antibody (7D5) (CBMAB-P1187-YC)

Datasheet

SDS

Target: PDE1A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7D5

Application*: WB, IH

Mouse Anti-PDE1A Recombinant Antibody (5H4) (CBMAB-P1186-YC)

Datasheet

SDS

Target: PDE1A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5H4

Application*: WB

Mouse Anti-PDE1A Recombinant Antibody (5C9) (CBMAB-P1185-YC)

Datasheet

SDS

Target: PDE1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C9

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)