PDE5A

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq]

Full Name

phosphodiesterase 5A, cGMP-specific

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

Biological Process

cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cardiac muscle contractionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of cardiac muscle hypertrophyIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Positive regulation of oocyte developmentIEA:Ensembl
Regulation of nitric oxide mediated signal transductionIEA:Ensembl
Relaxation of cardiac muscleIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytosol

PTM

Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity).
Phosphorylation by PRKG1 leads to its activation.