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PDE5A

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq]

Full Name

phosphodiesterase 5A, cGMP-specific

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

Biological Process

cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cardiac muscle contractionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of cardiac muscle hypertrophyIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Positive regulation of oocyte developmentIEA:Ensembl
Regulation of nitric oxide mediated signal transductionIEA:Ensembl
Relaxation of cardiac muscleIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytosol

PTM

Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity).
Phosphorylation by PRKG1 leads to its activation.

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Anti-PDE5A antibodies

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Mouse Anti-PDE5A Recombinant Antibody (1F11) (CBMAB-A6523-LY)

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Target: PDE5A

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 1F11

Application*: WB, E

Mouse Anti-PDE5A Recombinant Antibody (D-3) (CBMAB-P1223-YC)

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Target: PDE5A

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: D-3

Application*: WB, IP, IF, E

Mouse Anti-PDE5A Recombinant Antibody (9H5) (CBMAB-P1222-YC)

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Target: PDE5A

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 9H5

Application*: E, IF, WB

Mouse Anti-PDE5A Recombinant Antibody (CBYY-C0320) (CBMAB-C1078-YY)

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Target: PDE5A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-C0320

Application*: WB

Human Recombinant PDE5A, Active protein, GST Tag (V2LY-0526-LY6038)

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Target: PDE5A

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 537-end

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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