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Mouse Anti-PDE5A Recombinant Antibody (D-3) (CBMAB-P1223-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
D-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 5A, cGMP-specific
Introduction
PDE5A is a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.
Entrez Gene ID
8654
UniProt ID
O76074
Alternative Names
Phosphodiesterase 5A; Phosphodiesterase 5A, CGMP-Specific; EC 3.1.4.35; CGB-PDE; PDE5; CGMP-Binding CGMP-Specific 3,5-Cyclic Nucleotide Phosphodiesterase; CGMP-Binding CGMP-Specific Phosphodiesterase;
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).
Biological Process
cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cardiac muscle contractionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of cardiac muscle hypertrophyIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Positive regulation of oocyte developmentIEA:Ensembl
Regulation of nitric oxide mediated signal transductionIEA:Ensembl
Relaxation of cardiac muscleIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytosol
PTM
Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity).
Phosphorylation by PRKG1 leads to its activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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