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Mouse Anti-PDE5A Recombinant Antibody (CBYY-C0320) (CBMAB-C1078-YY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYY-C0320
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Rat cGB-PDE aa. 2-108
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
250 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 5A, cGMP-specific
Entrez Gene ID
171115
UniProt ID
O54735
Alternative Names
Interleukin 2 Receptor Subunit Gamma
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).
Biological Process
cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cardiac muscle contractionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of cardiac muscle hypertrophyIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Positive regulation of oocyte developmentIEA:Ensembl
Regulation of nitric oxide mediated signal transductionIEA:Ensembl
Relaxation of cardiac muscleIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytosol
PTM
Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity).
Phosphorylation by PRKG1 leads to its activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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