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PFDN6

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin and alpha-and beta-tubulin chains pending their transfer to the cytosolic chaperonin containing TCP1.

Full Name

Prefoldin Subunit 6

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Biological Process

Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of amyloid fibril formationManual Assertion Based On ExperimentIDA:FlyBase
Protein foldingManual Assertion Based On ExperimentIDA:FlyBase
Protein stabilization3 PublicationsIC:ComplexPortal

Cellular Location

chaperone complex
cytoplasm
prefoldin complex
RPAP3/R2TP/prefoldin-like complex

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Anti-PFDN6 antibodies

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Mouse Anti-PFDN6 Recombinant Antibody (4E10) (CBMAB-P1505-YC)

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Target: PFDN6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E10

Application*: IH, F, WB

Human PFDN6 ELISA Kit (V2LY-0626-LY5760)

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Target: PFDN6

Sensitivity: 0.004 ng/mL

Detection Range: 0.007-1.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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