PFDN6

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin and alpha-and beta-tubulin chains pending their transfer to the cytosolic chaperonin containing TCP1.

Full Name

Prefoldin Subunit 6

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Biological Process

Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of amyloid fibril formationManual Assertion Based On ExperimentIDA:FlyBase
Protein foldingManual Assertion Based On ExperimentIDA:FlyBase
Protein stabilization3 PublicationsIC:ComplexPortal

Cellular Location

chaperone complex
cytoplasm
prefoldin complex
RPAP3/R2TP/prefoldin-like complex

Anti-PFDN6 antibodies

Mouse Anti-PFDN6 Recombinant Antibody (4E10) (CBMAB-P1505-YC)

Datasheet

SDS

Target: PFDN6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E10

Application*: IH, F, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)