PGD
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
Full Name
PGD
Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Biological Process
D-gluconate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Pentose biosynthetic processIEA:Ensembl
Pentose-phosphate shuntISS:UniProtKB
Pentose-phosphate shunt, oxidative branchManual Assertion Based On ExperimentIDA:UniProtKB
Pentose biosynthetic processIEA:Ensembl
Pentose-phosphate shuntISS:UniProtKB
Pentose-phosphate shunt, oxidative branchManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
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Anti-PGD antibodies
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Target: PGD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P322
Application*: IC, IF
Target: PGD
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 46B3
Application*: WB, E, IC, IF
Target: PGD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A5
Application*: WB, P, IF, IC
Target: PGD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G12
Application*: E, IF, IH, WB
Target: PGD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1B6
Application*: E, M
Target: PGD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-5053
Application*: E, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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