PHF20

PHF20 has ubiquitous expression in testis (RPKM 8.8), brain (RPKM 8.0) and 25 other tissues.

Full Name

PHD Finger Protein 20

Function

Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Histone acetylationManual Assertion Based On ExperimentIBA:GO_Central
Histone H4-K16 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K4 methylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription, DNA-templated1 PublicationIC:ComplexPortal
Regulation of dosage compensation by inactivation of X chromosomeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus