PREX1

PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Full Name

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1

Function

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Biological Process

Actin filament polymerizationManual Assertion Based On ExperimentTAS:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Neutrophil activationManual Assertion Based On ExperimentTAS:UniProtKB
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of GTPase activityIEA:Ensembl
Positive regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Regulation of small GTPase mediated signal transductionTAS:Reactome
Superoxide metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl

Cellular Location

Cytoplasm, cytosol
Cell membrane
Mainly cytosolic. Some amount is apparently associated to the plasma membrane.