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Rabbit Anti-PREX1 Recombinant Antibody (D8D2K) (CBMAB-CP2072-LY)


See all PREX1 antibodies
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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D8D2K
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His770 of human PREX1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1
Entrez Gene ID
57580
UniProt ID
Q8TCU6
Function
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Biological Process
Actin filament polymerizationManual Assertion Based On ExperimentTAS:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Neutrophil activationManual Assertion Based On ExperimentTAS:UniProtKB
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of GTPase activityIEA:Ensembl
Positive regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Regulation of small GTPase mediated signal transductionTAS:Reactome
Superoxide metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Cell membrane
Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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