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Rabbit Anti-PREX1 Recombinant Antibody (D8O8D) (CBMAB-P2761-YC)

Provided herein is a Rabbit monoclonal antibody against Human Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1. The antibody can be used for immunoassay techniques, such as WB, IF.
See all PREX1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D8O8D
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1
Introduction
PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
Entrez Gene ID
Human57580
Monkey714351
UniProt ID
HumanQ8TCU6
MonkeyA0A5F8APA7
Alternative Names
P-REX1
Function
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Biological Process
Actin filament polymerizationManual Assertion Based On ExperimentTAS:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Neutrophil activationManual Assertion Based On ExperimentTAS:UniProtKB
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of GTPase activityIEA:Ensembl
Positive regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Regulation of small GTPase mediated signal transductionTAS:Reactome
Superoxide metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Cell membrane
Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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