Mouse Anti-PREX1 Recombinant Antibody (CBYC-P606) (CBMAB-P2760-YC)

Name: Mouse Anti-PREX1 Recombinant Antibody (CBYC-P606)
SKU: CBMAB-P2760-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYC-P606

Application

Immunogen

E. coli-derived Recombinant human P-Rex1, Lys1313-Arg1434

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1

Introduction

PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Entrez Gene ID

57580

UniProt ID

Q8TCU6

Alternative Names

P-REX1

Function

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Biological Process

Actin filament polymerizationManual Assertion Based On ExperimentTAS:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Neutrophil activationManual Assertion Based On ExperimentTAS:UniProtKB
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of GTPase activityIEA:Ensembl
Positive regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Regulation of small GTPase mediated signal transductionTAS:Reactome
Superoxide metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell differentiationIEA:Ensembl

Cellular Location

Cytoplasm, cytosol
Cell membrane
Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-PREX1 Recombinant Antibody (D8D2K) (CAT#: CBMAB-CP2072-LY)

Rabbit Anti-PREX1 Recombinant Antibody (D8O8D) (CAT#: CBMAB-P2761-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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