PRKAR2A

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Full Name
protein kinase cAMP-dependent type II regulatory subunit alpha
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Biological Process
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm
Cell membrane
Colocalizes with PJA2 in the cytoplasm and the cell membrane.
PTM
Phosphorylated by the activated catalytic chain.
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Anti-PRKAR2A antibodies

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Rabbit Anti-PRKAR2A Recombinant Antibody (EG1738) (CBMAB-EN2076-LY)

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Target: PRKAR2A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1738
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Datasheet SDS

Mouse Anti-PRKAR2A Recombinant Antibody (6A9) (CBMAB-A7038-LY)

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Target: PRKAR2A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6A9
Application*: WB, E
Datasheet SDS

Mouse Anti-PRKAR2A Recombinant Antibody (3C7) (CBMAB-A7037-LY)

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Target: PRKAR2A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C7
Application*: WB, E
Datasheet SDS

Rabbit Anti-PRKAR2A Recombinant Antibody (CBYC-P614) (CBMAB-P2815-YC)

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Target: PRKAR2A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P614
Application*: IF, IH, IP, WB
Datasheet SDS

Mouse Anti-PRKAR2A Recombinant Antibody (F-7) (CBMAB-P2814-YC)

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Target: PRKAR2A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: F-7
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PRKAR2A Recombinant Antibody (1A7) (CBMAB-P2812-YC)

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Target: PRKAR2A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7
Application*: F, IF, IH, WB
Datasheet SDS

Rabbit Anti-PRKAR2A Recombinant Antibody (
15G8) (V2LY-0725-LY1032)

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Target: PRKAR2A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 15G8
Application*: E, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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