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Mouse Anti-PRKAR2A Recombinant Antibody (3C7) (CBMAB-A7037-LY)

The product is antibody recognizes PRKAR2A. The antibody 3C7 immunoassay techniques such as: WB, ELISA.
See all PRKAR2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PRKAR2A (AAH02763, 1 a.a. ~ 105 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein kinase cAMP-dependent type II regulatory subunit alpha
Introduction
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq]
Entrez Gene ID
5576
UniProt ID
P13861
Alternative Names
MGC3606; PKR2; PRKAR2
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Biological Process
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm
Cell membrane
Colocalizes with PJA2 in the cytoplasm and the cell membrane.
PTM
Phosphorylated by the activated catalytic chain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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