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PTPN6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Full Name
PTPN6
Function
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Biological Process
Abortive mitotic cell cycleIEA:Ensembl
B cell receptor signaling pathwayIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayTAS:Reactome
Epididymis developmentIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hematopoietic progenitor cell differentiationIEA:Ensembl
Intracellular signal transductionIEA:Ensembl
Megakaryocyte developmentIEA:Ensembl
Natural killer cell mediated cytotoxicityIEA:Ensembl
Negative regulation of cell population proliferation1 PublicationNAS:UniProtKB
Negative regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Negative regulation of interleukin-6 productionISS:ARUK-UCL
Negative regulation of MAP kinase activityIEA:Ensembl
Negative regulation of mast cell activation involved in immune responseIEA:Ensembl
Negative regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of T cell proliferationIEA:Ensembl
Negative regulation of T cell receptor signaling pathwayIEA:Ensembl
Negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet aggregationIEA:Ensembl
Platelet formationIEA:Ensembl
Positive regulation of cell adhesion mediated by integrinIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of B cell differentiationIEA:Ensembl
Regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of release of sequestered calcium ion into cytosolIEA:Ensembl
Regulation of type I interferon-mediated signaling pathwayTAS:Reactome
T cell costimulationTAS:Reactome
Cellular Location
Cytoplasm
Nucleus
In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
Shuttles between the cytoplasm and nucleus via its association with PDPK1
PTM
Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity).
Phosphorylation at Tyr-564 enhances phosphatase activity.

Anti-PTPN6 antibodies

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Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10BA40
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA38
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PTY6
Application*: IC, IF, IP, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PTY15
Application*: E, IC, IF, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: PTY13
Application*: WB, IP, IC
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M160
Application*: WB, IP, E, IC
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3089
Application*: WB
Target: PTPN6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1737
Application*: IC
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1533
Application*: WB, P, IC, F
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-0062
Application*: WB, P, IF, IP, F
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: B5-A4
Application*: WB, P, IF
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F5
Application*: E, WB
Target: PTPN6
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-5989
Application*: WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5591
Application*: IC, IF, WB
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5576
Application*: IF
Target: PTPN6
Host: Mouse
Specificity: Human
Clone: CBFYH-3639
Application*: WB, IC, P, C, E
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0377
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0376
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0375
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0374
Application*: E, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0373
Application*: E, WB
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb201
Application*: WB, IH
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C14H6
Application*: WB
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D11G5
Application*: WB
Target: PTPN6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: Y476
Application*: IC, IF, WB, P, F, IP
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PTY11
Application*: E, C, IC, IF, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: PTY10
Application*: IC, IF, E, C, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 52/PTP1C/SHP1
Application*: WB, IF, IP
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E9E4
Application*: E, WB, IF, IC, F
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1SH01
Application*: P, IP, WB
Target: PTPN6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14D5
Application*: E, WB, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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