RAB11FIP5

RAB11FIP5 (RAB11 Family Interacting Protein 5) is a Protein Coding gene. Diseases associated with RAB11FIP5 include Neonatal Lupus Erythematosus and Atypical Autism. Among its related pathways are Endocytosis and Delta508-CFTR traffic / ER-to-Golgi in CF. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding and gamma-tubulin binding. An important paralog of this gene is RAB11FIP1.

Full Name

RAB11 family interacting protein 5 (class I)

Function

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.

Biological Process

Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Biological Process negative regulation of adiponectin secretionManual Assertion Based On ExperimentIDA:CACAO
Biological Process regulated exocytosisISS:UniProtKB
Biological Process regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Recycling endosome membrane
Early endosome membrane
Golgi apparatus membrane
Cytoplasmic vesicle, secretory vesicle membrane
Mitochondrion membrane

PTM

Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.