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RAPGEF4

RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Acrodysostosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of this gene is RAPGEF3.

Full Name

Rap Guanine Nucleotide Exchange Factor 4

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).

Biological Process

Biological Process adaptive immune responseTAS:Reactome
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process insulin secretionIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle cycleIEA:Ensembl

Cellular Location

Cytoplasm
Membrane

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Anti-RAPGEF4 antibodies

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Rabbit Anti-RAPGEF4 Recombinant Antibody (D3P3J) (CBMAB-CP2211-LY)

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Target: RAPGEF4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D3P3J

Application*: WB, IP

Mouse Anti-RAPGEF4 Recombinant Antibody (5B1) (CBMAB-R1351-CN)

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Target: RAPGEF4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 5B1

Application*: WB

Mouse Anti-RAPGEF4 Recombinant Antibody (1C11) (CBMAB-R1350-CN)

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Target: RAPGEF4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C11

Application*: E, WB

Mouse Anti-RAPGEF4 Recombinant Antibody (CBFYE-1616) (CBMAB-E2275-FY)

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Target: RAPGEF4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1616

Application*: WB

Human RAPGEF4 ELISA Kit (V2LY-0626-LY5156)

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Target: RAPGEF4

Sensitivity: 0.0077 ng/mL

Detection Range: 0.015-3 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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