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Mouse Anti-RAPGEF4 Recombinant Antibody (5B1) (CBMAB-R1351-CN)

This product is a Mouse antibody that recognizes RAPGEF4. The antibody 5B1 can be used for immunoassay techniques such as: WB.
See all RAPGEF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
5B1
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Rap Guanine Nucleotide Exchange Factor 4
Introduction
RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Acrodysostosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of this gene is RAPGEF3.
Entrez Gene ID
Human11069
Mouse56508
Rat252857
UniProt ID
HumanQ8WZA2
MouseQ9EQZ6
RatQ9Z1C7
Alternative Names
Rap Guanine Nucleotide Exchange Factor 4; CAMP-Regulated Guanine Nucleotide Exchange Factor II; Exchange Protein Directly Activated By CAMP 2; RAP Guanine-Nucleotide-Exchange Factor (GEF) 4; Rap Guanine Nucleotide Exchange Factor (GEF) 4; Exchange Factor Directly Activated By CAMP 2; CAMP-GEFII;
Function
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Biological Process
Biological Process adaptive immune responseTAS:Reactome
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process insulin secretionIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle cycleIEA:Ensembl
Cellular Location
Cytoplasm
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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