Mouse Anti-RAPGEF4 Recombinant Antibody (1C11) (CBMAB-R1350-CN)

Name: Mouse Anti-RAPGEF4 Recombinant Antibody (1C11)
SKU: CBMAB-R1350-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C11

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 1-110 from human RAPGEF4 (H24004) with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

Rap Guanine Nucleotide Exchange Factor 4

Introduction

RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Acrodysostosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of this gene is RAPGEF3.

Entrez Gene ID

11069

UniProt ID

Q8WZA2

Alternative Names

Rap Guanine Nucleotide Exchange Factor 4; CAMP-Regulated Guanine Nucleotide Exchange Factor II; Exchange Protein Directly Activated By CAMP 2; RAP Guanine-Nucleotide-Exchange Factor (GEF) 4; Rap Guanine Nucleotide Exchange Factor (GEF) 4; Exchange Factor Directly Activated By CAMP 2; CAMP-GEFII;

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).

Biological Process

Biological Process adaptive immune responseTAS:Reactome
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process insulin secretionIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle cycleIEA:Ensembl

Cellular Location

Cytoplasm
Membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Rabbit Anti-RAPGEF4 Recombinant Antibody (D3P3J) (CAT#: CBMAB-CP2211-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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