RBBP9
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
Full Name
RB Binding Protein 9, Serine Hydrolase
Function
Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647).
May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647).
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647).
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
Biological Process
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of cell population proliferationIEA:Ensembl
Biological Process response to nematodeIEA:Ensembl
Biological Process type II pneumocyte differentiationIEA:Ensembl
Biological Process regulation of cell population proliferationIEA:Ensembl
Biological Process response to nematodeIEA:Ensembl
Biological Process type II pneumocyte differentiationIEA:Ensembl
Cellular Location
Nucleoplasm
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Anti-RBBP9 antibodies
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Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF363
Application*: ELISA, WB, IHC
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF362
Application*: ELISA, WB, IF, IHC
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-290
Application*: WB
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-289
Application*: E, WB, IH
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-288
Application*: E, WB, IF, IH
Target: RBBP9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBCNR-287
Application*: WB, P, F, IF
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G9
Application*: WB, IH, IF, F
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G3
Application*: WB, IH, IF, F
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E1
Application*: IF, WB
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D5E11
Application*: E, WB, IH
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G2
Application*: WB, IF, F
Target: RBBP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C10
Application*: WB, IF, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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