RCN1
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane
Full Name
reticulocalbin 1, EF-hand calcium binding domain
Function
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Biological Process
Biological Process camera-type eye developmentIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Cellular Location
Endoplasmic reticulum lumen
PTM
O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.
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Anti-RCN1 antibodies
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Target: RCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-352
Application*: WB, IP, P, IF
Target: RCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-355
Application*: WB
Target: RCN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F8-E4
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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