RGN

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein. [provided by RefSeq]

regucalcin (senescence marker protein-30)

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca2+ signaling, and Ca2+-dependent cellular processes and enzyme activities (By similarity).

Biological Process agingIEA:Ensembl
Biological Process cellular calcium ion homeostasisISS:UniProtKB
Biological Process kidney developmentIEA:Ensembl
Biological Process L-ascorbic acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process liver regenerationIEA:Ensembl
Biological Process negative regulation of apoptotic processIEA:Ensembl
Biological Process negative regulation of bone developmentIEA:Ensembl
Biological Process negative regulation of calcium-dependent ATPase activityIEA:Ensembl
Biological Process negative regulation of cyclic-nucleotide phosphodiesterase activityIEA:Ensembl
Biological Process negative regulation of DNA biosynthetic processIEA:Ensembl
Biological Process negative regulation of DNA catabolic processIEA:Ensembl
Biological Process negative regulation of epithelial cell proliferationIEA:Ensembl
Biological Process negative regulation of flagellated sperm motilityIEA:Ensembl
Biological Process negative regulation of GTPase activityIEA:Ensembl
Biological Process negative regulation of leucine-tRNA ligase activityIEA:Ensembl
Biological Process negative regulation of nitric oxide biosynthetic processIEA:Ensembl
Biological Process negative regulation of phosphoprotein phosphatase activityIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process negative regulation of RNA biosynthetic processIEA:Ensembl
Biological Process positive regulation of ATP-dependent activityISS:UniProtKB
Biological Process positive regulation of ATPase-coupled calcium transmembrane transporter activityIEA:Ensembl
Biological Process positive regulation of dUTP diphosphatase activityIEA:Ensembl
Biological Process positive regulation of fatty acid biosynthetic processIEA:Ensembl
Biological Process positive regulation of glucose metabolic processIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of phosphatase activityIEA:Ensembl
Biological Process positive regulation of proteolysis involved in protein catabolic processIEA:Ensembl
Biological Process positive regulation of superoxide dismutase activityIEA:Ensembl
Biological Process positive regulation of triglyceride biosynthetic processIEA:Ensembl
Biological Process regulation of calcium-mediated signalingISS:UniProtKB
Biological Process spermatogenesisIEA:Ensembl

Cytoplasm