RGS1

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Full Name

Regulator Of G Protein Signaling 1

Function

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894).
Inhibits B cell chemotaxis toward CXCL12 (By similarity).
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).

Biological Process

Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukotriene signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Biological Process response to bacteriumIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Cytoplasm, cytosol