RIOK2

RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.
Full Name
RIO Kinase 2
Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402).
Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of ribosomal small subunit export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitotic metaphase/anaphase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Exported out of the nucleus via its NES in a XPO1-dependent manner.
PTM
Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710).
Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710).
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Anti-RIOK2 antibodies

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Human Recombinant RIOK2, Active protein, GST Tag (V2LY-0526-LY6549)

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Target: RIOK2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-552
Tag: GST Tag
Datasheet SDS

Human Recombinant RIOK2 protein, GST Tag (V2LY-0526-LY6548)

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Target: RIOK2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

RIOK2 Matched Antibody Pair (995) (APMAB-995LY)

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Target: RIOK2
Specificity: Human
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (CBCNR-516) (CBMAB-R2699-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNR-516
Application*: E, P, E
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (CBCNR-515) (CBMAB-R2698-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBCNR-515
Application*: IF, P, E
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (5D11) (CBMAB-R2697-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D11
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (3F6) (CBMAB-R2696-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F6
Application*: WB
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (3E11) (CBMAB-R2695-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: 3E11
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (2F4) (CBMAB-R2694-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F4
Application*: WB
Datasheet SDS

Mouse Anti-RIOK2 Recombinant Antibody (1B10) (CBMAB-R2693-CN)

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Target: RIOK2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B10
Application*: E, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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