Mouse Anti-RIOK2 Recombinant Antibody (5D11) (CBMAB-R2697-CN)

Name: Mouse Anti-RIOK2 Recombinant Antibody (5D11)
SKU: CBMAB-R2697-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5D11

Application

WB, IHC, FC

Immunogen

Human recombinant protein fragment corresponding to aa. 277-552 of human RIOK2 (NP_060813) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

More Infomation

Target

Full Name

RIO Kinase 2

Introduction

RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

Entrez Gene ID

55781

UniProt ID

Q9BVS4

Alternative Names

RIO Kinase 2; Serine/Threonine-Protein Kinase RIO2; RIO Kinase 2 (Yeast); EC 2.7.11.1; RIO2;

Function

Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402).
Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of ribosomal small subunit export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitotic metaphase/anaphase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Exported out of the nucleus via its NES in a XPO1-dependent manner.

PTM

Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710).
Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

RIOK2 Matched Antibody Pair (995) (CAT#: APMAB-995LY)

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RIOK2 Matched Antibody Pair (995) (CAT#: APMAB-995LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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