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Mouse Anti-RIOK2 Recombinant Antibody (1B10) (CBMAB-R2693-CN)

This product is a Mouse antibody that recognizes RIOK2. The antibody 1B10 can be used for immunoassay techniques such as: ELISA, IHC.
See all RIOK2 antibodies
Published Data
Fig.1 Rio2 interacts with Plk1.
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Fig.2 Plk1 phosphorylates Rio2 at the sites of Ser-335, Ser-380, and Ser-548.
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Fig.3 The putative promoters of riok-2 and -3 drive GFP in distinct tissues.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC

Basic Information

Immunogen
Partial recombinant corresponding to aa. 453-552 from human RIOK2 (H00953) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RIO Kinase 2
Introduction
RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.
Entrez Gene ID
55781
UniProt ID
Q9BVS4
Alternative Names
RIO Kinase 2; Serine/Threonine-Protein Kinase RIO2; RIO Kinase 2 (Yeast); EC 2.7.11.1; RIO2;
Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402).
Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of ribosomal small subunit export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitotic metaphase/anaphase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Exported out of the nucleus via its NES in a XPO1-dependent manner.
PTM
Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710).
Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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