ROBO2

The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Roundabout Guidance Receptor 2

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

Biological Process aorta developmentISS:BHF-UCL
Biological Process aortic valve morphogenesisISS:BHF-UCL
Biological Process apoptotic process involved in luteolysisManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process axon guidanceISS:UniProtKB
Biological Process axon midline choice point recognitionISS:UniProtKB
Biological Process brain developmentManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process central nervous system development1 PublicationNAS:UniProtKB
Biological Process endocardial cushion formationISS:BHF-UCL
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process metanephros developmentISS:UniProtKB
Biological Process negative regulation of negative chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of synapse assemblyISS:UniProtKB
Biological Process olfactory bulb interneuron developmentISS:UniProtKB
Biological Process outflow tract septum morphogenesisISS:BHF-UCL
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of Notch signaling pathway involved in heart inductionISS:BHF-UCL
Biological Process pulmonary valve morphogenesisISS:BHF-UCL
Biological Process retinal ganglion cell axon guidanceISS:UniProtKB
Biological Process ureteric bud developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ventricular septum morphogenesisISS:BHF-UCL

Membrane

Vesicoureteral reflux 2 (VUR2):
A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.

Extracellular: 22-859
Helical: 860-880
Cytoplasmic: 881-1378