SAR1A

SAR1A (Secretion Associated Ras Related GTPase 1A) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Delta508-CFTR traffic / ER-to-Golgi in CF. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is SAR1B.

Full Name

SAR1 homolog A (S. cerevisiae)

Function

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity).
Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Biological Process

Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of COPII vesicle coatingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle organizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum
Golgi apparatus