SERPINA1A

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Full Name

serine (or cysteine) peptidase inhibitor, clade A, member 1A

Function

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of serine-type endopeptidase activityISO:MGI
Biological Process protein N-linked glycosylationManual Assertion Based On ExperimentIDA:MGI
Biological Process response to chromateISO:MGI
Biological Process response to cytokineManual Assertion Based On ExperimentIDA:MGI
Biological Process response to lead ionISO:MGI
Biological Process response to methanolISO:MGI
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Secreted