SFTPC

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
Full Name
Surfactant Protein C
Function
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Biological Process
Respiratory gaseous exchange by respiratory system
Cellular Location
Secreted, extracellular space, surface film
Involvement in disease
Pulmonary surfactant metabolism dysfunction 2 (SMDP2):
A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Respiratory distress syndrome in premature infants (RDS):
A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
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Anti-SFTPC antibodies

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Mouse Anti-SFTPC Recombinant Antibody (CBXS-0319) (CBMAB-S3294-CQ)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXS-0319
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (4A10) (CBMAB-A8046-LY)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A10
Application*: WB, E
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (CBXS-2476) (CBMAB-S5233-CQ)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2476
Application*: E, WB
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (CBXS-0320) (CBMAB-S3295-CQ)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0320
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (CBXS-0318) (CBMAB-S3293-CQ)

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Target: SFTPC
Host: Mouse
Specificity: Human
Clone: CBXS-0318
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (CBXS-5662) (CBMAB-S0534-CQ)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5662
Application*: E, WB
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (5E6A9) (CBMAB-P3668-YC)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E6A9
Application*: WB, E
Datasheet SDS

Mouse Anti-SFTPC Recombinant Antibody (CBT3290) (V2LY-0625-LY2787)

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Target: SFTPC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3290
Application*: WB
Datasheet SDS

SFTPC Matched Antibody Pair (1081) (APMAB-1081LY)

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Target: SFTPC
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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