SLC8A2

SLC8A2 (Solute Carrier Family 8 Member A2) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is SLC8A3.

Full Name

Solute Carrier Family 8 Member A2

Function

Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca2+ and Na+ excretion.

Biological Process

Biological Process calcium ion export across plasma membraneISS:ARUK-UCL
Biological Process calcium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process calcium ion transmembrane transportISS:UniProtKB
Biological Process cell communicationIEA:InterPro
Biological Process cellular calcium ion homeostasisISS:UniProtKB
Biological Process cognitionISS:ARUK-UCL
Biological Process ion transportTAS:Reactome
Biological Process learningISS:UniProtKB
Biological Process learning or memoryISS:ARUK-UCL
Biological Process long-term synaptic potentiationISS:UniProtKB
Biological Process memoryISS:UniProtKB
Biological Process metal ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process modulation of excitatory postsynaptic potentialISS:ARUK-UCL
Biological Process neuron cellular homeostasisISS:ARUK-UCL
Biological Process positive regulation of protein serine/threonine kinase activityISS:ARUK-UCL
Biological Process regulation of action potential firing patternISS:ARUK-UCL
Biological Process regulation of calcineurin-mediated signalingISS:ARUK-UCL
Biological Process regulation of cardiac conductionTAS:Reactome
Biological Process regulation of cytosolic calcium ion concentrationISS:ARUK-UCL
Biological Process regulation of gene expressionISS:ARUK-UCL
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process response to ischemiaISS:ARUK-UCL
Biological Process sodium ion transmembrane transportISS:UniProtKB
Biological Process synapse organizationISS:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Cell membrane
Basolateral cell membrane
Perikaryon
Cell projection, dendrite
Cell projection, dendritic spine