SLC9A1

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others (Mattei et al., 1988 [PubMed 2846238]).[supplied by OMIM

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Biological Process cardiac muscle cell contractionIEA:Ensembl
Biological Process cardiac muscle cell differentiationIEA:Ensembl
Biological Process cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cellular response to antibioticIEA:Ensembl
Biological Process cellular response to coldIEA:Ensembl
Biological Process cellular response to electrical stimulusIEA:Ensembl
Biological Process cellular response to epinephrine stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process cellular response to mechanical stimulusManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process ion transportTAS:Reactome
Biological Process maintenance of cell polarityManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process negative regulation of apoptotic processIEA:Ensembl
Biological Process neuron deathIEA:Ensembl
Biological Process positive regulation of action potentialIEA:Ensembl
Biological Process positive regulation of apoptotic processIEA:Ensembl
Biological Process positive regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of calcium:sodium antiporter activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cardiac muscle hypertrophyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cell growthIEA:Ensembl
Biological Process positive regulation of mitochondrial membrane permeabilityIEA:Ensembl
Biological Process positive regulation of the force of heart contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein complex oligomerizationISS:UniProtKB
Biological Process proton transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of cardiac muscle cell membrane potentialManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of cardiac muscle contraction by calcium ion signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of focal adhesion assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of sensory perception of painIEA:Ensembl
Biological Process regulation of stress fiber assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of the force of heart contraction by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to acidic pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to muscle stretchManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process sodium ion export across plasma membraneISS:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process stem cell differentiationIEA:Ensembl

Membrane
Endoplasmic reticulum membrane
Cell membrane
Colocalizes with CHP1 at the reticulum endoplasmic (By similarity).
Colocalizes with CHP1 and CHP2 at the plasma membrane

Lichtenstein-Knorr syndrome (LIKNS):
An autosomal recessive neurologic disorder characterized by progressive cerebellar ataxia and severe progressive sensorineural hearing loss.

O-glycosylated.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).