SLITRK2

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.

Full Name

SLIT And NTRK Like Family Member 2

Function

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321).
Suppresses neurite outgrowth (By similarity).

Biological Process

Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of synapse assemblyISS:UniProtKB
Biological Process regulation of presynapse assemblyManual Assertion Based On ExperimentIDA:SynGO
Biological Process regulation of synapse organizationManual Assertion Based On ExperimentIDA:SynGO
Biological Process synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Membrane
Cell membrane

Topology

Extracellular: 22-621
Helical: 622-642
Cytoplasmic: 643-845