SNX6

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq]

Full Name

sorting nexin 6

Function

Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774).
The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988).
Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574).
May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142).
Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942).
In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity).
May contribute to transcription regulation (Probable).

Biological Process

Biological Process cellular response to amyloid-betaManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epidermal growth factor-activated receptor activity1 PublicationNAS:UniProtKB
Biological Process negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process regulation of macroautophagy1 PublicationNAS:ParkinsonsUK-UCL
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Early endosome
Early endosome membrane
Cytoplasmic vesicle
Cytoplasm
Nucleus
Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774).
Only a minor proportion is seen in the nucleus.

PTM

In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (PubMed:11591366).