SP110

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]
Full Name
SP110
Function
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Biological Process
Regulation of transcription by RNA polymerase II
Cellular Location
Nucleus
Found in the nuclear body.
Involvement in disease
Hepatic venoocclusive disease with immunodeficiency (VODI):
Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
PTM
Phosphorylated (isoform 2).
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Anti-SP110 antibodies

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Mouse Anti-SP110 Monoclonal Antibody (1D9) (CBMAB-0173-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D9
Application*: IP, M
Datasheet SDS

Mouse Anti-SP110 Monoclonal Antibody (1C5) (CBMAB-0172-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1C5
Application*: IP, M
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (8C8) (CBMAB-A8497-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8C8
Application*: WB, E
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (6F11) (CBMAB-A8496-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6F11
Application*: WB, E
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (4B8) (CBMAB-A8495-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B8
Application*: WB, E
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (2G10) (CBMAB-A8494-LY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G10
Application*: WB, E
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (CBXS-3172) (CBMAB-S5914-CQ)

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Target: SP110
Host: Mouse
Specificity: Human
Clone: CBXS-3172
Application*: E, WB
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (CBXS-2932) (CBMAB-S5681-CQ)

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Target: SP110
Host: Mouse
Specificity: Human
Clone: CBXS-2932
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SP110 (AA 232-521) Recombinant Antibody (CBXS-4327) (CBMAB-S1572-CQ)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4327
Application*: P, WB
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (CBXS-4224) (CBMAB-S1476-CQ)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4224
Application*: WB, IH
Datasheet SDS

Mouse Anti-SP110 (AA 232-521) Recombinant Antibody (CBXS-3913) (CBMAB-S1181-CQ)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3913
Application*: P, WB
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (CBXS-5927) (CBMAB-S0776-CQ)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5927
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-SP110 Recombinant Antibody (CBYY-I1330) (CBMAB-I2500-YY)

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Target: SP110
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I1330
Application*: E, IH, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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