SPTBN2

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
Full Name
spectrin, beta, non-erythrocytic 2
Function
Probably plays an important role in neuronal membrane skeleton.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Biological Process adult behaviorIEA:Ensembl
Biological Process cerebellar Purkinje cell layer morphogenesisIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process postsynapse organizationIEA:Ensembl
Biological Process synapse assemblyIEA:Ensembl
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Involvement in disease
Spinocerebellar ataxia 5 (SCA5):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.
Spinocerebellar ataxia, autosomal recessive, 14 (SCAR14):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR14 is characterized by delayed psychomotor development, severe early onset gait ataxia, eye movement abnormalities, cerebellar atrophy on brain imaging, and intellectual disability.
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Anti-SPTBN2 antibodies

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Mouse Anti-SPTBN2 Recombinant Antibody (4D9) (CBMAB-A8577-LY)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4D9
Application*: WB, E
Datasheet SDS

Mouse Anti-SPTBN2 Recombinant Antibody (SCNB3-1) (CBMAB-S6557-CQ)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: SCNB3-1
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-SPTBN2 Recombinant Antibody (CBXS-2039) (CBMAB-S4806-CQ)

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Target: SPTBN2
Host: Mouse
Specificity: Human
Clone: CBXS-2039
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SPTBN2 Recombinant Antibody (CBXS-1675) (CBMAB-S4517-CQ)

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Target: SPTBN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1675
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-SPTBN2 Recombinant Antibody (CBXS-5027) (CBMAB-S2249-CQ)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Mouse, Human
Clone: CBXS-5027
Application*: WB, IP, E
Datasheet SDS

Rabbit Anti-SPTBN2 Recombinant Antibody (CBXS-3727) (CBMAB-S1002-CQ)

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Target: SPTBN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3727
Application*: F, IC, IF
Datasheet SDS

Mouse Anti-SPTBN2 Recombinant Antibody (CBXS-4767) (CBMAB-S0083-CQ)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-4767
Application*: WB, IH, IF, P, F
Datasheet SDS

Mouse Anti-SPTBN2 Monoclonal Antibody (SPTBN2/1583) (CBMAB-1541-YC)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: SPTBN2/1583
Application*: P
Datasheet SDS

Mouse Anti-SPTBN2 Monoclonal Antibody (SPTBN2/1247) (CBMAB-1540-YC)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Rat
Clone: SPTBN2/1247
Application*: P
Datasheet SDS

Mouse Anti-SPTBN2 Monoclonal Antibody (SPTBN2/1584) (CBMAB-1539-YC)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: SPTBN2/1584
Application*: P
Datasheet SDS

Mouse Anti-SPTBN2 Monoclonal Antibody (SPTBN2/1582) (CBMAB-1538-YC)

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Target: SPTBN2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SPTBN2/1582
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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