ST8SIA6

This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants.

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6

Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,36-Gal sequence at the non-reducing end of their carbohydrate groups.

Biological Process blastocyst hatchingIEA:Ensembl
Biological Process carbohydrate biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process ganglioside biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process glycolipid biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process glycoprotein metabolic processBy SimilarityISS:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oligosaccharide metabolic processBy SimilarityISS:BHF-UCL
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein O-linked glycosylationBy SimilarityISS:BHF-UCL

Golgi apparatus membrane

Cytoplasmic: 1-3
Helical: 4-24
Lumenal: 25-398