ST8SIA6

This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants.

Full Name

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6

Function

Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,36-Gal sequence at the non-reducing end of their carbohydrate groups.

Biological Process

Biological Process blastocyst hatchingIEA:Ensembl
Biological Process carbohydrate biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process ganglioside biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process glycolipid biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process glycoprotein metabolic processBy SimilarityISS:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oligosaccharide metabolic processBy SimilarityISS:BHF-UCL
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein O-linked glycosylationBy SimilarityISS:BHF-UCL

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-3
Helical: 4-24
Lumenal: 25-398