STARD4

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).

Full Name

StAR Related Lipid Transfer Domain Containing 4

Function

Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.

Biological Process

Biological Process cholesterol importManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cholesterol transport involved in cholesterol storageManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intracellular cholesterol transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of bile acid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cholesterol metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

cytoplasm
cytoplasmic vesicle
cytosol
endoplasmic reticulum